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Small-molecule mediated neuroprotection in an in situ model of tauopathy

Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer’s disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previousl...

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Autores principales: Honson, Nicolette S., Jensen, Jordan R., Abraha, Aida, Hall, Garth F., Kuret, Jeff
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740339/
https://ncbi.nlm.nih.gov/pubmed/19384600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9028-y
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