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ULTRAVIOLET IRRADIATION INDUCES SMAD7 VIA INDUCTION OF TRANSCRIPTION FACTOR AP-1 IN HUMAN SKIN FIBROBLASTS

Smad7 functions as an endogenous negative regulator of TGF-β/Smad signaling. TGF-β/Smad pathway is a major regulator of collagen production in connective tissue. Reduced expression of Smad7 has been reported in TGF-β-mediated fibrotic diseases, characterized by over production of collagen. Solar ult...

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Detalhes bibliográficos
Main Authors: Quan, Taihao, He, Tianyuan, Voorhees, John J., Fisher, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738262/
https://ncbi.nlm.nih.gov/pubmed/15579469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409647200
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