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ULTRAVIOLET IRRADIATION INDUCES SMAD7 VIA INDUCTION OF TRANSCRIPTION FACTOR AP-1 IN HUMAN SKIN FIBROBLASTS
Smad7 functions as an endogenous negative regulator of TGF-β/Smad signaling. TGF-β/Smad pathway is a major regulator of collagen production in connective tissue. Reduced expression of Smad7 has been reported in TGF-β-mediated fibrotic diseases, characterized by over production of collagen. Solar ult...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3738262/ https://ncbi.nlm.nih.gov/pubmed/15579469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409647200 |
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