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Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts

Exposure to oxidants results in cellular alterations that are implicated in aging and age-associated diseases. Here, we report that brief, low-level oxidative exposure leads to long-term elevation of cellular reactive oxygen species (ROS) levels and oxidative damage in human skin fibroblasts. Elevat...

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Hlavní autoři: He, Tianyuan, Quan, Taihao, Shao, Yuan, Voorhees, John J., Fisher, Gary J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082581/
https://ncbi.nlm.nih.gov/pubmed/24550076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-014-9623-6
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