Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory...

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Detalhes bibliográficos
Main Authors: Wang, Zhi-Gang, Chen, Liqun, Chen, Jiebo, Zheng, Jian-Feng, Gao, Weiwei, Zeng, Zhiping, Zhou, Hu, Zhang, Xiao-kun, Huang, Pei-Qiang, Su, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738195/
https://ncbi.nlm.nih.gov/pubmed/23434637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.01.012
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