RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner

The major oncogenic driver of acute promyelocytic leukemia (APL) is the fusion protein PML-RARα originated from the chromosomal translocation t(15;17). All-trans retinoic acid (ATRA) and arsenic trioxide cure most patients by directly targeting PML-RARα. However, major issues including the resistanc...

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Vydáno v:Oncotarget
Hlavní autoři: Xu, Lin, Zeng, Zhiping, Zhang, Weidong, Ren, Gaoang, Ling, Xiaobin, Huang, Fengyu, Xie, Peizhen, Su, Ying, Zhang, Xiao-kun, Zhou, Hu
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355346/
https://ncbi.nlm.nih.gov/pubmed/28129653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14812
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