Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells

In developing B cells, the immunoglobulin heavy chain (IgH) locus is thought to move from repressive to permissive chromatin compartments to facilitate its scheduled rearrangement. In mature B cells, maintenance of allelic exclusion has been proposed to involve recruitment of the non-productive IgH...

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Hlavní autoři: Holwerda, Sjoerd J. B., van de Werken, Harmen J. G., Ribeiro de Almeida, Claudia, Bergen, Ingrid M., de Bruijn, Marjolein J. W., Verstegen, Marjon J. A. M., Simonis, Marieke, Splinter, Erik, Wijchers, Patrick J., Hendriks, Rudi W., de Laat, Wouter
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737562/
https://ncbi.nlm.nih.gov/pubmed/23748562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt491
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