Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells

In developing B cells, the immunoglobulin heavy chain (IgH) locus is thought to move from repressive to permissive chromatin compartments to facilitate its scheduled rearrangement. In mature B cells, maintenance of allelic exclusion has been proposed to involve recruitment of the non-productive IgH...

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Библиографические подробности
Главные авторы: Holwerda, Sjoerd J. B., van de Werken, Harmen J. G., Ribeiro de Almeida, Claudia, Bergen, Ingrid M., de Bruijn, Marjolein J. W., Verstegen, Marjon J. A. M., Simonis, Marieke, Splinter, Erik, Wijchers, Patrick J., Hendriks, Rudi W., de Laat, Wouter
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2013
Предметы:
Gene Regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737562/
https://ncbi.nlm.nih.gov/pubmed/23748562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt491
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