Variegated gene expression caused by cell-specific long-range DNA interactions

Mammalian genomes contain numerous regulatory DNA sites with unknown target genes. We used mice with an extra β-globin locus control region (LCR) to investigate how a regulator searches the genome for target genes. We find that the LCR samples a restricted nuclear subvolume, wherein it preferentiall...

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Detalhes bibliográficos
Main Authors: Noordermeer, Daan, de Wit, Elzo, Klous, Petra, van de Werken, Harmen, Simonis, Marieke, Lopez-Jones, Melissa, Eussen, Bert, de Klein, Annelies, Singer, Robert H., de Laat, Wouter
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151580/
https://ncbi.nlm.nih.gov/pubmed/21706023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2278
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