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Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1

The CUG-BP, Elav-like family (CELF) of RNA-binding proteins control gene expression at a number of different levels by regulating pre-mRNA splicing, deadenylation and mRNA stability. We present structural insights into the binding selectivity of CELF member 1 (CELF1) for GU-rich mRNA target sequence...

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Détails bibliographiques
Auteurs principaux: Edwards, John M., Long, Jed, de Moor, Cornelia H., Emsley, Jonas, Searle, Mark S.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737555/
https://ncbi.nlm.nih.gov/pubmed/23748565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt470
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