Conserved GU-Rich Elements Mediate mRNA Decay by Binding to CUG-Binding Protein 1

We used computational algorithms to find conserved sequences in the 3′ untranslated region (UTR) of transcripts that exhibited rapid decay in primary human T cells and found that the consensus sequence UGUUUGUUUGU, which we have termed a GU-rich element (GRE), was enriched in short-lived transcripts...

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Auteurs principaux: Vlasova, Irina A., Tahoe, Nuzha M., Fan, Danhua, Larsson, Ola, Rattenbacher, Bernd, SternJohn, Julius R., Vasdewani, Jayprakash, Karypis, George, Reilly, Cavan S., Bitterman, Peter B., Bohjanen, Paul R.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367162/
https://ncbi.nlm.nih.gov/pubmed/18243120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.11.024
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