Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N—terminal RRMs of CELF1

CUGBP, Elav-like family member 1 (CELF1) is an RNA binding protein with important roles in the regulation of splicing, mRNA decay and translation. CELF1 contains three RNA recognition motifs (RRMs). We used gel retardation, gel filtration, isothermal titration calorimetry and NMR titration studies t...

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Detalhes bibliográficos
Main Authors: Edwards, John, Malaurie, Emilie, Kondrashov, Alexander, Long, Jed, de Moor, Cornelia H., Searle, Mark S., Emsley, Jonas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201864/
https://ncbi.nlm.nih.gov/pubmed/21743084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr510
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