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Inactivation of CUG-BP1/CELF1 Causes Growth, Viability, and Spermatogenesis Defects in Mice

CUG-BP1/CELF1 is a multifunctional RNA-binding protein involved in the regulation of alternative splicing and translation. To elucidate its role in mammalian development, we produced mice in which the Cugbp1 gene was inactivated by homologous recombination. These Cugbp1(−)(/)(−) mice were viable, al...

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Bibliographische Detailangaben
Hauptverfasser: Kress, Chantal, Gautier-Courteille, Carole, Osborne, H. Beverley, Babinet, Charles, Paillard, Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800704/
https://ncbi.nlm.nih.gov/pubmed/17130239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01009-06
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