Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N—terminal RRMs of CELF1

CUGBP, Elav-like family member 1 (CELF1) is an RNA binding protein with important roles in the regulation of splicing, mRNA decay and translation. CELF1 contains three RNA recognition motifs (RRMs). We used gel retardation, gel filtration, isothermal titration calorimetry and NMR titration studies t...

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Autors principals: Edwards, John, Malaurie, Emilie, Kondrashov, Alexander, Long, Jed, de Moor, Cornelia H., Searle, Mark S., Emsley, Jonas
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201864/
https://ncbi.nlm.nih.gov/pubmed/21743084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr510
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