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A role for p38 in transcriptional elongation of p21(CIP1) in response to Aurora B inhibition
Aurora kinases play important functions in mitosis. They are overexpressed in many cancers and are targets for anticancer therapy. Inhibition of Aurora B results in cytokinesis failure and polyploidization, leading to activation of the p53 tumor suppressor and its target genes, including p21. The pa...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737308/ https://ncbi.nlm.nih.gov/pubmed/23759594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25100 |
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