Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1)

Aurora kinase B is a critical component of the chromosomal passenger complex, which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis. By using conditional knockout cells and chemical inhibition, we show here that inactivation of Aurora B results in delayed G(1)/S...

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Main Authors: Trakala, Marianna, Fernández-Miranda, Gonzalo, Pérez de Castro, Ignacio, Heeschen, Christopher, Malumbres, Marcos
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646860/
https://ncbi.nlm.nih.gov/pubmed/23428904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24004
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