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Transcription Factor Sp3 Represses Expression of p21(CIP1) via Inhibition of Productive Elongation by RNA Polymerase II

Like that of many protein-coding genes, expression of the p21(CIP1) cell cycle inhibitor is regulated at the level of transcription elongation. While many transcriptional activators have been shown to stimulate elongation, the mechanisms by which promoter-specific repressors regulate pausing and elo...

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Autors principals: Valin, Alvaro, Ouyang, Jian, Gill, Grace
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624253/
https://ncbi.nlm.nih.gov/pubmed/23401853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00323-12
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