The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice

BACKGROUND: Clostridium difficile mediates intestinal inflammation by releasing toxin A (TxA), a potent enterotoxin. Cathelicidins (Camp as gene name, LL-37 peptide in humans and mCRAMP peptide in mice) are antibacterial peptides that also posses anti-inflammatory properties. OBJECTIVES: To determin...

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Main Authors: Hing, Tressia C, Ho, Samantha, Shih, David Q, Ichikawa, Ryan, Cheng, Michelle, Chen, Jeremy, Chen, Xinhua, Law, Ivy, Najarian, Robert, Kelly, Ciaran P, Gallo, Richard L, Targan, Stephan R, Pothoulakis, Charalabos, Koon, Hon Wai
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737259/
https://ncbi.nlm.nih.gov/pubmed/22760006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-302180
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