The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the s...

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Detalhes bibliográficos
Main Authors: Postepska-Igielska, Anna, Krunic, Damir, Schmitt, Nina, Greulich-Bode, Karin M, Boukamp, Petra, Grummt, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736129/
https://ncbi.nlm.nih.gov/pubmed/23797874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.87
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