The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the s...

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Hlavní autoři: Postepska-Igielska, Anna, Krunic, Damir, Schmitt, Nina, Greulich-Bode, Karin M, Boukamp, Petra, Grummt, Ingrid
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736129/
https://ncbi.nlm.nih.gov/pubmed/23797874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.87
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