The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

Maintenance of specific heterochromatic domains is crucial for genome stability. In eukaryotic cells, a fraction of the tandem-repeated ribosomal RNA (rRNA) genes is organized in the heterochromatic structures. The principal determinant of rDNA silencing is the nucleolar remodelling complex, NoRC, t...

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Autors principals: Guetg, Claudio, Lienemann, Philipp, Sirri, Valentina, Grummt, Ingrid, Hernandez-Verdun, Danièle, Hottiger, Michael O, Fussenegger, Martin, Santoro, Raffaella
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905252/
https://ncbi.nlm.nih.gov/pubmed/20168299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.17
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