To trim or not to trim: Progression and control of DSB end resection

DNA double-strand breaks (DSBs) are the most cytotoxic form of DNA damage, since they can lead to genome instability and chromosome rearrangements, which are hallmarks of cancer cells. To face this kind of lesion, eukaryotic cells developed two alternative repair pathways, homologous recombination (...

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Hlavní autoři: Granata, Magda, Panigada, Davide, Galati, Elena, Lazzaro, Federico, Pellicioli, Achille, Plevani, Paolo, Muzi-Falconi, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
Perspective
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735699/
https://ncbi.nlm.nih.gov/pubmed/23708517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25042
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