Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling Pathway

Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis. Polo kinases (Plks) are fundamental regulators of cell cycle progression in all eukaryotes and are frequently overexpressed...

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Autori principali: Donnianni, Roberto Antonio, Ferrari, Matteo, Lazzaro, Federico, Clerici, Michela, Tamilselvan Nachimuthu, Benjamin, Plevani, Paolo, Muzi-Falconi, Marco, Pellicioli, Achille
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797610/
https://ncbi.nlm.nih.gov/pubmed/20098491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000763
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