Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling Pathway

Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis. Polo kinases (Plks) are fundamental regulators of cell cycle progression in all eukaryotes and are frequently overexpressed...

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Detalhes bibliográficos
Main Authors: Donnianni, Roberto Antonio, Ferrari, Matteo, Lazzaro, Federico, Clerici, Michela, Tamilselvan Nachimuthu, Benjamin, Plevani, Paolo, Muzi-Falconi, Marco, Pellicioli, Achille
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797610/
https://ncbi.nlm.nih.gov/pubmed/20098491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000763
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