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New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca(2+) cycling: Dual effects of ivabradine on Ca(2+) and membrane clocks

Beneficial clinical bradycardic effects of ivabradine (IVA) have been interpreted solely on the basis of I(f) inhibition, because IVA specifically inhibits I(f) in sinoatrial nodal pacemaker cells (SANC). However, it has been recently hypothesized that SANC normal automaticity is regulated by crosst...

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書誌詳細
主要な著者: Yaniv, Yael, Sirenko, Syevda, Ziman, Bruce D., Spurgeon, Harold A., Maltsev, Victor A., Lakatta, Edward G.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735682/
https://ncbi.nlm.nih.gov/pubmed/23651631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.04.026
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