New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca(2+) cycling: Dual effects of ivabradine on Ca(2+) and membrane clocks

Beneficial clinical bradycardic effects of ivabradine (IVA) have been interpreted solely on the basis of I(f) inhibition, because IVA specifically inhibits I(f) in sinoatrial nodal pacemaker cells (SANC). However, it has been recently hypothesized that SANC normal automaticity is regulated by crosst...

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Detalhes bibliográficos
Main Authors: Yaniv, Yael, Sirenko, Syevda, Ziman, Bruce D., Spurgeon, Harold A., Maltsev, Victor A., Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735682/
https://ncbi.nlm.nih.gov/pubmed/23651631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.04.026
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