Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis

We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect was reproduced in NB4 APL cells, and shown to depend on activation of the gen...

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Detalhes bibliográficos
Main Authors: Gausdal, G, Wergeland, A, Skavland, J, Nguyen, E, Pendino, F, Rouhee, N, McCormack, E, Herfindal, L, Kleppe, R, Havemann, U, Schwede, F, Bruserud, Ø, Gjertsen, B T, Lanotte, M, Ségal-Bendirdjian, E, Døskeland, S O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734820/
https://ncbi.nlm.nih.gov/pubmed/23449452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.39
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