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Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen

BACKGROUND: The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline treatment such as lesions in haematopoietic tissues like the spleen. We used a Trp5...

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Hlavní autoři: Herfindal, Lars, Myhren, Lene, Gjertsen, Bjørn Tore, Døskeland, Stein Ove, Gausdal, Gro
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710475/
https://ncbi.nlm.nih.gov/pubmed/23841896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-341
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