Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen

BACKGROUND: The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline treatment such as lesions in haematopoietic tissues like the spleen. We used a Trp5...

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Main Authors: Herfindal, Lars, Myhren, Lene, Gjertsen, Bjørn Tore, Døskeland, Stein Ove, Gausdal, Gro
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710475/
https://ncbi.nlm.nih.gov/pubmed/23841896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-341
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