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Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action

Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death. Their intracellular targets are the major serine/threonine protein phosphatases. This review summarizes mechanisms...

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Bibliografiske detaljer
Udgivet i:Mar Drugs
Main Authors: Kleppe, Rune, Herfindal, Lars, Døskeland, Stein Ove
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626703/
https://ncbi.nlm.nih.gov/pubmed/26506362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13106505
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