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Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation
Human telomerase, a cellular reverse transcriptase (hTERT), is a nuclear ribonucleoprotein enzyme complex that catalyzes the synthesis and extension of telomeric DNA. This enzyme is specifically activated in most malignant tumors but is usually inactive in normal somatic cells, suggesting that telom...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34517/ https://ncbi.nlm.nih.gov/pubmed/11371621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111464998 |
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