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Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation

Human telomerase, a cellular reverse transcriptase (hTERT), is a nuclear ribonucleoprotein enzyme complex that catalyzes the synthesis and extension of telomeric DNA. This enzyme is specifically activated in most malignant tumors but is usually inactive in normal somatic cells, suggesting that telom...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pendino, Frédéric, Flexor, Maria, Delhommeau, François, Buet, Dorothée, Lanotte, Michel, Ségal-Bendirdjian, Evelyne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2001
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC34517/
https://ncbi.nlm.nih.gov/pubmed/11371621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111464998
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