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Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation

Human telomerase, a cellular reverse transcriptase (hTERT), is a nuclear ribonucleoprotein enzyme complex that catalyzes the synthesis and extension of telomeric DNA. This enzyme is specifically activated in most malignant tumors but is usually inactive in normal somatic cells, suggesting that telom...

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Bibliografische gegevens
Hoofdauteurs: Pendino, Frédéric, Flexor, Maria, Delhommeau, François, Buet, Dorothée, Lanotte, Michel, Ségal-Bendirdjian, Evelyne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC34517/
https://ncbi.nlm.nih.gov/pubmed/11371621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111464998
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