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The role of the allosteric B site in the fumarase reaction
The role of a malate binding site in a concavity external to the more deeply situated active site has been a major mystery of the fumarase reaction. The malate, within 12 Å of the active site, was bound by hydrogen bonds to two main-chain amides and to two basic residues, H129 and R126. Mutation of...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373472/ https://ncbi.nlm.nih.gov/pubmed/14990798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307524101 |
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