Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease

Both genetic inactivation and pharmacological inhibition of the cholesteryl ester synthetic enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1) have shown benefit in mouse models of Alzheimer's disease (AD). In this study, we aimed to test the potential therapeutic applications of adeno-assoc...

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Hlavní autoři: Murphy, Stephanie R, Chang, Catherine CY, Dogbevia, Godwin, Bryleva, Elena Y, Bowen, Zachary, Hasan, Mazahir T, Chang, Ta-Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734664/
https://ncbi.nlm.nih.gov/pubmed/23774792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.118
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