Determination of detection and quantification limits for SNP allele frequency estimation in DNA pools using real time PCR

The quantification of single nucleotide polymorphism (SNP) allele frequencies in pooled DNA samples using real time PCR is a promising approach for large-scale diagnostics and genotyping. The limits of detection (LOD) and limits of quantification (LOQ) for mutant SNP alleles are of particular import...

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izdano v:	Nucleic Acids Res
Principais autores:	Schwarz, Gerhard, Bäumler, Stefan, Block, Annette, Felsenstein, Friedrich G., Wenzel, Gerhard
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 2004
Teme:	NAR Methods Online
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14960708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gnh020
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