Determination of detection and quantification limits for SNP allele frequency estimation in DNA pools using real time PCR

The quantification of single nucleotide polymorphism (SNP) allele frequencies in pooled DNA samples using real time PCR is a promising approach for large-scale diagnostics and genotyping. The limits of detection (LOD) and limits of quantification (LOQ) for mutant SNP alleles are of particular import...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Schwarz, Gerhard, Bäumler, Stefan, Block, Annette, Felsenstein, Friedrich G., Wenzel, Gerhard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2004
Schlagworte:	NAR Methods Online
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14960708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gnh020
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