Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway

BACKGROUND: Cofilin is a member of the actin depolymerizing factor (ADF)/cofilin family, which regulates actin dynamics. Increasing evidence suggests that mitochondrial translocation of cofilin appears necessary for the regulation of apoptosis. RESULTS: We report that allyl isothiocyanate (AITC) pot...

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Detalhes bibliográficos
Main Authors: Li, Guo-bing, Cheng, Qi, Liu, Lei, Zhou, Ting, Shan, Chang-yu, Hu, Xiao-ye, Zhou, Jing, Liu, E-hu, Li, Ping, Gao, Ning
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734051/
https://ncbi.nlm.nih.gov/pubmed/23895248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-50
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