Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases (HDACs). These enzymes alter the acetylation of several proteins, including...

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Hlavní autoři: Fredly, Hanne, Gjertsen, Bjørn Tore, Bruserud, Øystein
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733883/
https://ncbi.nlm.nih.gov/pubmed/23898968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-5-12
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