Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases (HDACs). These enzymes alter the acetylation of several proteins, including...

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Main Authors: Fredly, Hanne, Gjertsen, Bjørn Tore, Bruserud, Øystein
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733883/
https://ncbi.nlm.nih.gov/pubmed/23898968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-5-12
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