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Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis
Cyclin D1 levels are maintained at steady state by phosphorylation-dependent nuclear export and polyubiquitination by the SCF(FBX4-αB crystallin) E3 ligase. Inhibition of cyclin D1 proteolysis has been implicated as a causative factor leading to its overexpression in carcinomas of the breast and eso...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733559/ https://ncbi.nlm.nih.gov/pubmed/17724472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210738 |
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