Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis

Cyclin D1 levels are maintained at steady state by phosphorylation-dependent nuclear export and polyubiquitination by the SCF(FBX4-αB crystallin) E3 ligase. Inhibition of cyclin D1 proteolysis has been implicated as a causative factor leading to its overexpression in carcinomas of the breast and eso...

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Bibliografiske detaljer
Main Authors: Lin, Douglas I., Lessie, Matthew D., Gladden, Andrew B., Bassing, Craig H., Wagner, Kay-Uwe, Diehl, J. Alan
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733559/
https://ncbi.nlm.nih.gov/pubmed/17724472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210738
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