Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to neoplasia are poorly understood. We now provide e...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Aggarwal, Priya, Lessie, Matthew D., Lin, Douglas I., Pontano, Laura, Gladden, Andrew B., Nuskey, Beth, Goradia, Ami, Wasik, Mariusz A., Klein-Szanto, Andres J.P., Rustgi, Anil K., Bassing, Craig H., Diehl, J. Alan
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2007
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049193/
https://ncbi.nlm.nih.gov/pubmed/18006686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1586007
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires