Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to neoplasia are poorly understood. We now provide e...

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Hlavní autoři: Aggarwal, Priya, Lessie, Matthew D., Lin, Douglas I., Pontano, Laura, Gladden, Andrew B., Nuskey, Beth, Goradia, Ami, Wasik, Mariusz A., Klein-Szanto, Andres J.P., Rustgi, Anil K., Bassing, Craig H., Diehl, J. Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2007
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049193/
https://ncbi.nlm.nih.gov/pubmed/18006686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1586007
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