Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage

The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein. Geminin depletion...

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Autori principali: Hall, Jonathan R., Lee, Hyun O., Bunker, Brandon D., Dorn, Elizabeth S., Rogers, Greg C., Duronio, Robert J., Cook, Jeanette Gowen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533066/
https://ncbi.nlm.nih.gov/pubmed/18617514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802667200
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