Hepatitis B Virus X Protein Increases the Cdt1-to-Geminin Ratio Inducing DNA Re-replication and Polyploidy

Hepatitis B virus X protein (pX) is implicated in hepatocellular carcinoma pathogenesis by an unknown mechanism. Employing the tetracycline-regulated pX-expressing 4pX-1 cell line, derived from the murine AML12 hepatocyte cell line, we demonstrate that pX induces partial polyploidy (>4N DNA). Dep...

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Detalhes bibliográficos
Main Authors: Rakotomalala, Lova, Studach, Leo, Wang, Wen-Horng, Gregori, Gerald, Hullinger, Ronald L., Andrisani, Ourania
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568909/
https://ncbi.nlm.nih.gov/pubmed/18693245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802751200
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