Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy

Hepatitis B virus X protein (pX), implicated in hepatocarcinogenesis, induces DNA damage because of re-replication and allows propagation of damaged DNA, resulting in partial polyploidy and oncogenic transformation. The mechanism by which pX allows cells with DNA damage to continue proliferating is...

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Detalhes bibliográficos
Main Authors: Studach, Leo, Wang, Wen-Horng, Weber, Gregory, Tang, Jiabin, Hullinger, Ronald L., Malbrue, Raphael, Liu, Xiaoqi, Andrisani, Ourania
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943266/
https://ncbi.nlm.nih.gov/pubmed/20624918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093963
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