Polo-like kinase1 inhibition suppresses Hepatitis B virus X protein-induced transformation, in an in vitro model of liver cancer progression

Chronic Hepatitis B virus (HBV) infection is linked to development of hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis acting as a weak oncogene or a co-factor in hepatocarcinogenesis. pX induces DNA re-replication, DNA damage and partial polyploidy in a poorl...

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Main Authors: Studach, Leo L., Rakotomalala, Lova, Wang, Wen-Horng, Hullinger, Ronald L., Cairo, Stefano, Buendia, Marie-Annick, Andrisani, Ourania M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788305/
https://ncbi.nlm.nih.gov/pubmed/19472310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22996
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