Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

There is a need to improve treatments for metastatic breast cancer. Here we show activation of the phosphoinositide 3-kinase (PI3K) and MAP kinase (MAPK) pathways in a MMTV-CreBRCA1(f/f)p53+/− mouse model of breast cancer. When treated with the pan-Class IA PI3K-inhibitor NVP-BKM120, tumor doubling...

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Detalhes bibliográficos
Main Authors: Juvekar, Ashish, Burga, Laura N., Hu, Hai, Lunsford, Elaine P., Ibrahim, Yasir H., Balmañà, Judith, Rajendran, Anbazhagan, Papa, Antonella, Spencer, Katherine, Lyssiotis, Costas A., Nardella, Caterina, Pandolfi, Pier Paolo, Baselga, Jose, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733368/
https://ncbi.nlm.nih.gov/pubmed/22915751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0336
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