Gliadin-primed CD4+CD45RBlowCD25− T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice

BACKGROUND AND AIMS: Celiac disease (cd) is a common small intestinal inflammatory disorder that results from a breach of intestinal tolerance to dietary gluten proteins, driven by gluten-reactive effector T cells. We aimed to assess the pathogenic role of gluten-reactive effector T cells and to gen...

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Main Authors: Freitag, Tobias L., Rietdijk, Svend, Junker, Yvonne, Popov, Yury, Bhan, Atul K., Kelly, Ciaran P., Terhorst, Cox, Schuppan, Detlef
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733237/
https://ncbi.nlm.nih.gov/pubmed/19671544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2009.186361
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