Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis

The pathogenesis of human inflammatory bowel disease (IBD) and most experimental models of IBD is dependent on the activation and expansion of CD4(+) T cells via interaction with mucosal antigen-presenting cells. The costimulatory receptor CD70 is transiently expressed on the surface of conventional...

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Udgivet i:J Immunol
Main Authors: Manocha, Monika, Rietdijk, Svend, Laouar, Amale, Liao, Gongxian, Bhan, Atul, Borst, Jannie, Terhorst, Cox, Manjunath, N.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232384/
https://ncbi.nlm.nih.gov/pubmed/19525396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802424
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