Human DNA Glycosylase NEIL1’s Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival

NEIL1 is unique among the oxidatively damaged base repair-initiating DNA glycosylases in the human genome due to its S phase-specific activation and ability to excise substrate base lesions from single-stranded DNA. We recently characterized NEIL1’s specific binding to downstream canonical repair an...

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Hauptverfasser: Hegde, Muralidhar L., Hegde, Pavana M., Arijit, Dutta, Boldogh, Istvan, Mitra, Sankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733129/
https://ncbi.nlm.nih.gov/pubmed/23926464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom2040564
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