A novel assay to determine the sequence preference and affinity of DNA minor groove binding compounds

Sequence-specific binding in the minor groove of DNA by small molecules is a growing area of research with possible therapeutic relevance. By selectively binding to DNA sequences required by critical transcription factors, these small molecules could potentially modulate the expression levels of dis...

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Bibliographic Details
Main Authors: Thomas, Rita, Gonzalez, Carolyn, Roberts, Christopher, Botyanszki, Janos, Lou, Lillian, Michelotti, Emil F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
Subjects:
NAR Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC373301/
https://ncbi.nlm.nih.gov/pubmed/14718553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gng155
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