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A novel assay to determine the sequence preference and affinity of DNA minor groove binding compounds
Sequence-specific binding in the minor groove of DNA by small molecules is a growing area of research with possible therapeutic relevance. By selectively binding to DNA sequences required by critical transcription factors, these small molecules could potentially modulate the expression levels of dis...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373301/ https://ncbi.nlm.nih.gov/pubmed/14718553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gng155 |
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