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A novel assay to determine the sequence preference and affinity of DNA minor groove binding compounds

Sequence-specific binding in the minor groove of DNA by small molecules is a growing area of research with possible therapeutic relevance. By selectively binding to DNA sequences required by critical transcription factors, these small molecules could potentially modulate the expression levels of dis...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Thomas, Rita, Gonzalez, Carolyn, Roberts, Christopher, Botyanszki, Janos, Lou, Lillian, Michelotti, Emil F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC373301/
https://ncbi.nlm.nih.gov/pubmed/14718553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gng155
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